منابع مشابه
Identifying Potential Regions of Copy Number Variation for Bipolar Disorder
Bipolar disorder is a complex psychiatric disorder with high heritability, but its genetic determinants are still largely unknown. Copy number variation (CNV) is one of the sources to explain part of the heritability. However, it is a challenge to estimate discrete values of the copy numbers using continuous signals calling from a set of markers, and to simultaneously perform association testin...
متن کاملRapid Publication Increase in GSK3b Gene Copy Number Variation in Bipolar Disorder
The analysis of submicroscopic copy number variations (CNVs), also known as copy number polymorphisms (CNPs), is emerging as a new tool for understanding the genetic basis of cancer, developmental disorders, and complex traits. One area where this may be particularly useful is in the identification of genetic variants underlying schizophrenia (SZ) and bipolar disorder (BD). Linkage analysis and...
متن کاملBIRC5 Genomic Copy Number Variation in Early-Onset Breast Cancer
Background: Baculoviral inhibitor of apoptosis repeat-containing 5 (BIRC5) gene is an inhibitor of apoptosis that expresses in human embryonic tissues but it is absent in most healthy adult tissues. The copy number of BIRC5 has been indicated to be highly increased in tumor tissues; however, its association with the age of onset in breast cancer is not well understood. Methods: Forty tumor tiss...
متن کاملNo evidence for an involvement of copy number variation in ABCA13 in schizophrenia, bipolar disorder, or major depressive disorder.
Institute of Human Genetics, Department of Genomics, Life and Brain Center, Institute for Genomic Mathematics, Department of Psychiatry, University of Bonn, German Center for Neurodegenerative Diseases (DZNE), Bonn, Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, University of Heidelberg, Mannheim, Department of Psychiatry and Psychotherapy, Jena University...
متن کاملCopy-number variation in the pathogenesis of autism spectrum disorder.
Autism spectrum disorder is a neurodevelopmental disorder present in 1% of the population, characterized by impairments in reciprocal social interaction, communication deficits and restricted patterns of behavior. Approximately 10% of the autism spectrum disorder population is thought to have large chromosomal rearrangements. Copy-number variations (CNV) alter the genome structure either by dup...
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ژورنال
عنوان ژورنال: Molecular Psychiatry
سال: 2015
ISSN: 1359-4184,1476-5578
DOI: 10.1038/mp.2014.174